What is an Abnormal Chromosome Structure?
Abnormal Chromosome Structure is caused by a chromosomal mutation and can affect protein structure and function. Although there are some chromosomal abnormalities that happen after conception, abnormal chromosome structure most often occurs as an accident in either an egg or a sperm. There is also the possibility that a child may inherit an abnormal chromosome structure from his or her parents.
LESSON OVERVIEW (SPECIFIC EXPECTATIONS: D2.1, D3.1, D3.2, D3.4)
Lesson Hook:
The following video by Paul Andersen is a great way to recap the concept of the relationship between mutations and genetic disorders, as well as introduce the idea of abnormal chromosome structure.
Abnormal Chromosome Structure is caused by a chromosomal mutation and can affect protein structure and function. Although there are some chromosomal abnormalities that happen after conception, abnormal chromosome structure most often occurs as an accident in either an egg or a sperm. There is also the possibility that a child may inherit an abnormal chromosome structure from his or her parents.
LESSON OVERVIEW (SPECIFIC EXPECTATIONS: D2.1, D3.1, D3.2, D3.4)
Lesson Hook:
The following video by Paul Andersen is a great way to recap the concept of the relationship between mutations and genetic disorders, as well as introduce the idea of abnormal chromosome structure.
Misconceptions Addressed:
a.Students often think that all mutations are bad
b.Students often think any change will result in a genetic disorder
Pedagogy:
Using the above video is a great way to springboard a class discussion about chromosomal abnormalities and about abnormal chromosome structure in specific which can then be cemented with a group activity such as "determining the chromosomal abnormality". Students can use the image provided above as a guide to identifying abnormal chromosome structures OR students can use a fantastic flash animation call Chromosome Viewer courtesy of PBS. This viewer allows students to view the genes present within each individual chromosome but also allows provides specific information on the affects of different mutations associated with it. It also comes with sample discussion questions and background information for teachers.
Debrief:
A great way to check for understanding would be to have students watch the following animation courtesy of McGraw-Hill and then have them preforming a 3-2-1 using the following headings:
List 3 Similarities between point mutations and chromosomal mutations
List 2 Differences between an abnormal chromosome structure (such as a deletion) and a gene segment that has the same abnormality
List 1 Question you still have
to hand in at the end of class as an assessment for learning before continuing on to abnormal chromosome number.
FOPP: Commitment to students and student learning, leadership in learning communities, professional knowledge and professional practice.
a.Students often think that all mutations are bad
b.Students often think any change will result in a genetic disorder
Pedagogy:
Using the above video is a great way to springboard a class discussion about chromosomal abnormalities and about abnormal chromosome structure in specific which can then be cemented with a group activity such as "determining the chromosomal abnormality". Students can use the image provided above as a guide to identifying abnormal chromosome structures OR students can use a fantastic flash animation call Chromosome Viewer courtesy of PBS. This viewer allows students to view the genes present within each individual chromosome but also allows provides specific information on the affects of different mutations associated with it. It also comes with sample discussion questions and background information for teachers.
Debrief:
A great way to check for understanding would be to have students watch the following animation courtesy of McGraw-Hill and then have them preforming a 3-2-1 using the following headings:
List 3 Similarities between point mutations and chromosomal mutations
List 2 Differences between an abnormal chromosome structure (such as a deletion) and a gene segment that has the same abnormality
List 1 Question you still have
to hand in at the end of class as an assessment for learning before continuing on to abnormal chromosome number.
FOPP: Commitment to students and student learning, leadership in learning communities, professional knowledge and professional practice.